Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Barlind, J.G.; Buckett, L.K.; Crosby, S.G.; Davidsson, O.e.; Emtenaes, H.; Ertan, A.; Jurva, U.; Lemurell, M.; Gutierrez, P.M.; Nilsson, K.; OMahony, G.; Petersson, A.U.; Redzic, A.; Wagberg, F.; Yuan, Z.Q.
    Identification and design of a novel series of MGAT2 inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 2721-2726.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.22 drug development [acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome Homo sapiens
2.3.1.22 pharmacology [acyl CoA]monoacylglycerol acyltransferase 2 (MGAT2) is of interest as a target for therapeutic treatment of diabetes, obesity and other diseases which together constitute the metabolic syndrome Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.22 3,3-dimethyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 3-ethyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 3-ethyl-3-methyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 3-ethyl-3-methyl-2,5-dioxo-N-[4-(trifluoromethyl)phenyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 3-ethyl-N,3-dimethyl-2,5-dioxo-N-phenyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 3-ethyl-N-(4-methoxyphenyl)-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 additional information identification, development, and optimisation of a novel series of MGAT2 inhibitors, pIC50 values, overview Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3,3-diethyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3,3-diethyl-N-methyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3,3-diethyl-N-methyl-2-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3,3-diethyl-N-methyl-5-oxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3-ethyl-N,3,4-trimethyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2,4-difluorophenyl)-3-methyl-2,5-dioxo-3-propyl-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(2-chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(3-chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-7-yl)benzenesulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-2,5-dioxo-1,2,4,5-tetrahydrospiro[1,4-benzodiazepine-3,1'-cyclobutane]-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-2,5-dioxo-1,2,4,5-tetrahydrospiro[1,4-benzodiazepine-3,1'-cyclopentane]-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-3-ethyl-N,1,3-trimethyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-N,3,3-trimethyl-5-oxo-2,3,4,5-tetrahydro-1,4-benzoxazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-(4-chlorophenyl)-N-methyl-2,5-dioxo-1,2,4,5-tetrahydrospiro[1,4-benzodiazepine-3,1'-cyclobutane]-7-carboxamide
-
 Homo sapiens
2.3.1.22 N-benzyl-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-cyclohexyl-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens
2.3.1.22 N-[4-(difluoromethoxy)phenyl]-3-ethyl-3-methyl-2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-sulfonamide
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.22 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.22 Homo sapiens Q3SYC2
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.22 hepatocyte
-
 Homo sapiens
-
2.3.1.22 liver
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.3.1.22 Mgat2
-
 Homo sapiens
2.3.1.22 [acyl CoA]monoacylglycerol acyltransferase 2
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.22 additional information
-
 MGAT2 inhibitors, pIC50 values, overview Homo sapiens additional information

General Information

EC Number General Information Comment Organism
2.3.1.22 physiological function the enzyme is involved in diabetes, obesity and other diseases which together constitute the metabolic syndrome Homo sapiens